Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Chlophedianol; Dexchlorpheniramine; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Aliskiren; Amlodipine: (Moderate) Aliskiren can enhance the effects of vasodilators on blood pressure if given concomitantly. 0.25 mg/kg/dose (Max: 25 mg/dose) PO every 6 to 8 hours as needed is recommended for severely hypertensive patients with non-life-threatening symptoms. Although hydralazine has been administered safely to these patients, with no exacerbation of underlying disease, and the mechanism of hydralazine-induced lupus syndrome appears to be distinct from idiopathic lupus, hydralazine should nevertheless be used cautiously in this population. Increase the dose as needed. The manufacturer advises that IV diazoxide should not be administered to patients within 6 hours of receiving hydralazine. Apresoline/Hydralazine Hydrochloride Oral Tab: 10mg, 25mg, 50mg, 100mgHydralazine Hydrochloride Intramuscular Inj Sol: 1mL, 20mgHydralazine Hydrochloride Intravenous Inj Sol: 1mL, 20mg. Separate multiple email address with a comma. Includes HydrALAZINE indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Due to fluid retention, plasma volume increases. Isoflurane: (Moderate) General anesthetics can potentiate the hypotensive effects of antihypertensive agents. This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Ephedrine; Guaifenesin: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Teratogenic effects observed were cleft palate and malformations of facial and cranial bones. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. Hydralazine hydrochloride injection should be used only when the drug cannot be given orally. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Check BP in 20 minutes and if either BP threshold is exceeded, give 10 mg IV over 2 minutes. Max: 7.5 mg/kg/day. Although clinical experience does not identify evidence of fetal adverse effects, use hydralazine during pregnancy only if the expected benefit outweighs the potential risk to the fetus. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Anginal pain may be induced when coronary insufficiency is present. Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Use hydralazine cautiously in patients with an aortic aneurysm. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Apomorphine: (Moderate) Concurrent use of apomorphine and vasodilators can cause greater decreases in blood pressure than use of apomorphine alone. hydralazine is indicated for iv administration during hospitalization for severely elevated bp and is contraindicated in patients with documented hypersensitivity to the drug or any component of the formulation, coronary artery disease, or mitral valve rheumatic heart disease. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Switch to oral antihypertensive therapy as soon as possible, usually within 24 to 48 hours. Hydralazine is given alone or as an adjunct therapy to other antihypertensive drugs. Dexmedetomidine: (Moderate) Concomitant administration of dexmedetomidine and vasodilators could lead to additive hypotension and bradycardia; use together with caution. Inject undiluted injection IV via Y-site or a 3-way stopcock at a rate of 10 mg over at least 1 minute. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Anginal pain may be induced when coronary insufficiency is present. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Anginal pain may be induced when coronary insufficiency is present. Pharmacist may prepare oral solution from hydralazine injection for patients with difficulty swallowing. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. It works by relaxing blood vessels, which decreases blood pressure and the amount of work the heart has to do. Switch to oral antihypertensive therapy as soon as possible, usually within 24 to 48 hours. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. 0.25 to 1 mg/kg/dose PO every 6 to 8 hours, initially. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Tizanidine: (Moderate) Concurrent use of tizanidine with antihypertensive agents can result in significant hypotension. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Anginal pain may be induced when coronary insufficiency is present. Carbinoxamine; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. No other pharmacokinetic data on hydralazine hydrochloride injection are available. Estradiol; Norethindrone: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Anginal pain may be induced when coronary insufficiency is present. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Dextromethorphan; Guaifenesin; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Ibritumomab Tiuxetan: (Moderate) Use sodium phosphates cautiously with hydralazine as concurrent use can cause hypernatremia. It is difficult to provide guidelines regarding administration of hydralazine to patients with preexisting systemic lupus erythematosus (SLE). Anginal pain may be induced when coronary insufficiency is present. Diphenhydramine; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Midodrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Benzphetamine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Methylphenidate: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Max: 300 mg/day. This additive effect may be desirable, but dosages must be adjusted accordingly. Chlorpheniramine; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Anginal pain may be induced when coronary insufficiency is present. Anginal pain may be induced when coronary insufficiency is present. Aldesleukin, IL-2: (Moderate) Vasodilators may potentiate the hypotension seen with aldesleukin, IL 2. Repeat as needed, usually every 4 to 6 hours. When switching from IV to oral therapy, the IV dose should generally be doubled and administered orally; titrate the oral dose to response. Anginal pain may be induced when coronary insufficiency is present. Each mL of the sterile, nonpyrogenic colorless solution contains hydralazine hydrochloride USP, 20 mg; methylparaben NF, 0.65 mg; propylparaben NF, 0.35 mg; propylene glycol USP, 103.6 mg, and . Anginal pain may be induced when coronary insufficiency is present. Blood pressure and electrolytes should be routinely monitored in patients receiving aliskiren. Max: 0.4 mg/kg/dose, up to 20 mg/dose. Anginal pain may be induced when coronary insufficiency is present. Due to its unpredictable response and prolonged duration of action, hydralazine is not a desirable first-line agent for acute treatment. Codeine; Phenylephrine; Promethazine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. The antihypertensive effects of an IV dose last 26 hours on average, although the effects of a parenteral dose can last up to 12 hours; the affinity of hydralazine for arterial walls may partially explain the prolonged effect. 5-10 mg IV/IM initially, THEN 5-10 mg q20-30min PRN, OR 0.5-10 mg/hr IV infusion Congestive Heart Failure Initial dose: 10-25 mg PO q6-8hr; titrate dose q2-4weeks Maintenance dose: 225-300 mg/day. Brompheniramine; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. 0.1 to 0.2 mg/kg/dose IV every 4 hours as needed for blood pressure control. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Anginal pain may be induced when coronary insufficiency is present. Each milliliter of the sterile, nonpyrogenic colorless solution contains hydralazine hydrochloride USP, 20 mg, propylene glycol USP, 103.6 mg, and water for injection q.s. INTRAMUSCULAR INJECTIONS - Drug absorption is more rapid than sub Q. Loratadine; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Acetaminophen; Guaifenesin; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Concomitant use may result in additive hypotension. Etonogestrel; Ethinyl Estradiol: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Isosorbide Dinitrate, ISDN: (Moderate) Monitor blood pressure during concomitant hydralazine and nitrate use due to risk for additive hypotension. Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. It may be advisable to monitor blood pressure. Hydralazine may be eliminated more slowly in geriatric patients. It is possible that additive reductions in blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Pharmaceutical composition for inhibiting the formation of advanced glycosylation end products of proteins, comprising a mixture of an effective amount of a 2-(N-(2-aminoethyl)acetic acid derivative of the formula I ##STR5## in which R denotes phenyl, thienyl, furyl, pyridyl, pyrrolyl, imidazolyl or thiazolyl, or phenyl, thienyl, furyl, pyridyl, pyrrolyl, imidazolyl or thiazolyl which is . Nesiritide, BNP: (Moderate) The potential for hypotension may be increased when coadministering nesiritide with vasodilators. Aliskiren; Valsartan: (Moderate) Aliskiren can enhance the effects of vasodilators on blood pressure if given concomitantly. Administer consistently with regards to timing around meals/food to ensure consistent oral absorption of hydralazine. There is also evidence suggesting hydralazine exerts a positive inotropic effect on the failing human ventricle. Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous: (Moderate) Use sodium phosphates cautiously with hydralazine as concurrent use can cause hypernatremia. 0.1 to 0.2 mg/kg/dose IM every 4 hours as needed for blood pressure control. Subsequent dosage adjustments should be made based on clinical response. Cleveland Clinic is a non-profit academic medical center. Ibuprofen; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. 0.75 mg/kg/day PO in 4 divided doses (Max: 25 mg/dose), initially. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Milrinone: (Moderate) Concurrent administration of antihypertensive agents could lead to additive hypotension when administered with milrinone. Some agents require a gradual taper to avoid adverse consequences caused by abrupt discontinuation. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Switch to oral therapy as soon as possible, usually within 24 to 48 hours. Ethinyl Estradiol; Norgestrel: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Carcinogenesis, Mutagenesis, Impairment of Fertility: In a lifetime study in Swiss albino mice, there was a Patients who are slow acetylators as well as patients with decreased renal function are more likely than fast acetylators to develop lupus-like symptoms or potentially other hydralazine toxicity. Anginal pain may be induced when coronary insufficiency is present. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Cariprazine: (Moderate) Orthostatic vital signs should be monitored in patients who are at risk for hypotension, such as those receiving cariprazine in combination with antihypertensive agents. Concentration: 20 mg/mL. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Potassium Phosphate; Sodium Phosphate: (Moderate) Use sodium phosphates cautiously with hydralazine as concurrent use can cause hypernatremia. Aliskiren: (Moderate) Aliskiren can enhance the effects of vasodilators on blood pressure if given concomitantly. If indicated, dosage of the antihypertensive agents should be reduced. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Do not stop taking hydralazine without talking to your doctor. As veterinary medicines are biologically active compounds, there is a concern that their occurrence in the environment may have an adverse impact on aquatic and terrestrial organisms. Patients receiving a combination of apomorphine and vasodilators should be closely monitored for hypotension and orthostasis. The accumulation of oxidative free radicals creates an environment where chronic reductions in NO bioavailability contribute to a loss of skeletal muscle microvessels. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. When switching from IV to oral therapy, the IV dose should generally be doubled and administered orally; titrate the oral dose to response. Alprostadil: (Minor) The concomitant use of systemic alprostadil injection and antihypertensive agents, such as the vasodilators, may cause additive hypotension. Risperidone: (Moderate) Risperidone may induce orthostatic hypotension and thus enhance the hypotensive effects of antihypertensive agents. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Sevoflurane: (Moderate) General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Apraclonidine: (Minor) Alpha blockers as a class may reduce heart rate and blood pressure. Use hydralazine cautiously in patients with acute stroke or cerebral vascular accident as hydralazine in this setting can further worsen brain function. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Cabergoline has been associated with hypotension. Hydralazine, minoxidil, and sodium nitroprusside are antihypertensive agents used in infants that act as direct vasodilators Hydralazine is a direct vasodilator with an . Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Patients with renal impairment should receive the drug every 8 hours. Dexmethylphenidate: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Anginal pain may be induced when coronary insufficiency is present. Hydralazine is distributed into human milk. Anginal pain may be induced when coronary insufficiency is present. - A dose greater than 3 ml is usually divided and given at different sites. Traditionally, intravenous hydralazine (Apresoline) or labetalol (Trandate) have been used. Promethazine; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Chlorpheniramine; Ibuprofen; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Cocaine: (Major) Use of cocaine with antihypertensive agents may increase the antihypertensive effects of the antihypertensive medications or may potentiate cocaine-induced sympathetic stimulation. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Anginal pain may be induced when coronary insufficiency is present. . Check BP in 20 minutes and if either threshold is exceeded, switch to labetalol 20 mg IV over 2 minutes and check BP in 10 minutes. We do not record any personal information entered above. Paliperidone: (Moderate) Paliperidone may cause orthostatic hypotension, thereby enhancing the hypotensive effects of antihypertensive agents. Anginal pain may be induced when coronary insufficiency is present. Systemic drug interactions with the urethral suppository (MUSE) or alprostadil intracavernous injection are unlikely in most patients because low or undetectable amounts of the drug are found in the peripheral venous circulation following administration. - The volume of the solution for an IM injection is 0.5-3 ml with the average of 1-2 ml. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. If possible, patients should not take their antihypertensive medication 24 hours before receiving amifostine. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Alemtuzumab: (Moderate) Alemtuzumab may cause hypotension. Epoprostenol: (Major) Further reductions in blood pressure may occur when vasodilators are combined with epoprostenol. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Hydralazine can be administered intramuscularly or as a rapid IV injection. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. one method to the administration of being pregnant in ladies on anticoagulants is to change to subcutaneous low-molecular-weight heparin from the time of the first missed period and remain on this till term, sustaining a high intake of elemental calcium, as well as adequate however not excessive intake of vitamin d. around the time of supply, it Anginal pain may be induced when coronary insufficiency is present. Chlorpheniramine; Dihydrocodeine; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Other uses for this medicine Intravenous Administration Inject undiluted injection IV via Y-site or a 3-way stopcock at a rate of 10 mg over at least 1 minute. A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Anginal pain may be induced when coronary insufficiency is present. WARNINGS This additive effect may be desirable, but dosages must be adjusted accordingly. Ethynodiol Diacetate; Ethinyl Estradiol: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. and enhance the anti-hypertensive effect. Guaifenesin; Hydrocodone; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Dextromethorphan; Quinidine: (Moderate) Quinidine can decrease blood pressure and should be used cautiously in patients receiving antihypertensive agents due to the potential for additive hypotension. Anginal pain may be induced when coronary insufficiency is present. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. If hypotension occurs, dose reduction of one or both drugs may be needed and supportive measures instituted. Anginal pain may be induced when coronary insufficiency is present. Concurrent use with baclofen and antihypertensive agents may result in additive hypotension. Estradiol Cypionate; Medroxyprogesterone: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Isoproterenol: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. If either BP threshold is still exceeded, give labetalol 40 mg IV over 2 minutes, obtain emergency consultation, and give additional antihypertensive medication per specific order. Dihydroergotamine: (Minor) The combined use of vasodilators and the ergot alkaloids will likely result in antagonism of the vasoconstrictive effects of the ergot derivative. Hydralazine hydrochloride injection may discolor upon contact with metal; discolored solutions should be discarded. Conjugated Estrogens; Bazedoxifene: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Anginal pain may be induced when coronary insufficiency is present. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Administration: IV injection: Reconstitute one 20mg hydralazine vial with 1mL water for injection then make up to 20mL with sodium chloride 0.9% to make a concentration of 1 mg/mL. Blood pressure and electrolytes should be routinely monitored in patients receiving aliskiren. Procainamide: (Moderate) Procainamide can decrease blood pressure and should be used cautiously in patients receiving antihypertensive agents. Blood pressure and electrolytes should be routinely monitored in patients receiving aliskiren. Lovastatin; Niacin: (Moderate) Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents, especially peripheral vasodilators. injection of lidocaine/adrenaline . Estradiol: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Acetaminophen; Dextromethorphan; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Titrate milrinone dosage according to hemodynamic response. Naproxen; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. ( C , D ) Blood pressure responses with Ang II and with subsequent Ech A administration were compared between the Ang II rats and the Ang II plus Ech A rats. The usual dose is 20-40 mg, repeated as necessary. INDICATIONS AND USAGE: When dosing hydralazine in the elderly, it may be prudent to start the dose at the low end of the dosing range and monitor the patients closely for hypotensive effects. Continue to take hydralazine even if you feel well. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Seventy-sev en patients with eclampsia and hypertensive emergencies comprised the target population. Traductions en contexte de "hydralazine over other parenteral" en anglais-franais avec Reverso Context : A recent meta-analysis has shown no superiority of hydralazine over other parenteral drugs. Patients who can not stop their antihypertensive agents should not receive amifostine or be closely monitored during the infusion and, possibly, given lower doses. Chloroprocaine: (Moderate) Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Consider a cariprazine dose reduction if hypotension occurs. Mestranol; Norethindrone: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Anginal pain may be induced when coronary insufficiency is present. [60742] The federal Omnibus Budget Reconciliation Act (OBRA) regulates medication use in residents of long-term care facilities (LTCFs). Switch to oral antihypertensive therapy as soon as possible, usually within 24 to 48 hours. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Anginal pain may be induced when coronary insufficiency is present. 10 to 20 mg IV every 4 to 6 hours as needed. (SR) 20-30 mg daily Hydralazine 25 mg bd ^Nifedipine (IR) 10 . Procaine: (Moderate) Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Use caution with in-clinic dosing for erectile dysfunction (ED) and monitor for the effects on blood pressure. Anginal pain may be induced when coronary insufficiency is present. Hydralazine also maintains or increases renal and cerebral blood flow. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Hydralazine Link is used to reduce very high blood pressure especially during late pregnancy. Estropipate: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Switch to oral therapy as soon as possible, usually within 24 to 48 hours. Levodopa: (Moderate) Concomitant use of antihypertensive agents with levodopa can result in additive hypotensive effects. Amphetamine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Diethylstilbestrol, DES: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. However, in clinical trials with alprostadil intracavernous injection, anti-hypertensive agents had no apparent effect on the safety and efficacy of alprostadil. Aliskiren; Hydrochlorothiazide, HCTZ: (Moderate) Aliskiren can enhance the effects of vasodilators on blood pressure if given concomitantly. High blood pressure adds to the workload of the heart and arteries. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Amphetamine; Dextroamphetamine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Hydralazine injection is used to treat high blood pressure (hypertension). DOSAGE AND ADMINISTRATION When there is urgent need, therapy in the hospitalized patient may be initiated intramuscularly or as a rapid intravenous bolus injection directly into the vein. Oxymetazoline: (Major) The vasoconstricting actions of oxymetazoline, an alpha adrenergic agonist, may reduce the antihypertensive effects produced by vasodilators. Tranylcypromine: (Major) Avoid concomitant use of vasodilators and tranylcypromine due to the risk of additive hypotension. Epinephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. This interaction is used to clinical benefit, i.e., nitroprusside used for supportive care of ergot alkaloid toxicity. Additive hypotensive effects are possible. Anginal pain may be induced when coronary insufficiency is present. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. Rasagiline: (Moderate) Monoamine oxidase inhibitors (MAOIs) potentiate the concentration of catecholamines in the CNS. Hydralazine is subject to polymorphic acetylation; slow acetylation status results in higher plasma levels of hydralazine and these patients require lower doses to maintain control of blood pressure. It is a peripheral arterial vasodilator and causes relaxation of blood vessels which carry blood away from the heart and towards the organs and tissues. Initially, 10 to 50 mg IM. Anginal pain may be induced when coronary insufficiency is present. However, both vasodilators and dexmeditomidine may cause symptomatic hypotension. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Overview Condition that develops from the heart's inability to fill with or eject blood efficiently, resulting in reduced cardiac output and increased fluid buildup in the heart and/or lungs Usually due to a structural or functional disorder that impairs ventricular systolic or diastolic function Types of heart . to a friend, relative, colleague or yourself. Norgestimate; Ethinyl Estradiol: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. The average maximal decrease in blood pressure usually occurs 10 to 80 minutes after administration of hydralazine hydrochloride injection. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Check your blood pressure as you have been told. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Unlike thiopentone and propofol, it has a favourable haemodynamic profile and so can be useful in haemodynamically compromised patients. If these drugs are used together, closely monitor for changes in blood pressure. Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Cabergoline: (Moderate) Cabergoline should be used cautiously with antihypertensive agents, including hydralazine. Concomitant administration of prazosin with other antihypertensive agents is not prohibited, however. Levonorgestrel; Ethinyl Estradiol; Ferrous Bisglycinate: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Anginal pain may be induced when coronary insufficiency is present. Orthostatic vital signs should be monitored in patients receiving paliperidone and hydralazine who are susceptible to hypotension. As a result, tolerance can develop, which may account for the absence of improvement in some patients receiving the drug for prolonged periods of time. Max: 1.7 to 3.5 mg/kg/day. Continuous infusion: Women requiring a continuous infusion should be cared for in Acute Care or Delivery Suite. HYDRALAZINE (Apresoline R) Classification: vasodilator - antihypertensive agent. Isosorbide Mononitrate: (Moderate) Monitor blood pressure during concomitant hydralazine and nitrate use due to risk for additive hypotension. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. As an antihypertensive, hydralazine does not lead to improvements in LVH. The exact mechanism of how hydralazine causes arterial smooth muscle relaxation is not yet understood. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Max: 0.4 mg/kg/dose, up to 20 mg/dose. Chlophedianol; Guaifenesin; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Estradiol; Norgestimate: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. Anginal pain may be induced when coronary insufficiency is present. Amifostine: (Major) Patients receiving antihypertensive agents should be closely monitored during amifostine infusions due to additive effects. Anginal pain may be induced when coronary insufficiency is present. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Hypotensive effects occur 2030 minutes following an oral dose. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Diseases and Conditions: Heart failure. Ethinyl Estradiol: (Minor) The administration of estrogens can increase fluid retention, which increases blood pressure, thereby antagonizing the antihypertensive effects of hydralazine. No other pharmacokinetic data on hydralazine hydrochloride injection are available. Isocarboxazid: (Moderate) Monoamine oxidase inhibitors (MAOIs) potentiate the concentration of catecholamines in the CNS. Anginal pain may be induced when coronary insufficiency is present. Repeat as needed, usually every 4 to 6 hours initially. In hypertensive patients with normal kidneys who are treated with hydralazine, there is evidence of increased renal blood flow and a maintenance of glomerular filtration rate (GFR). Specific guidelines for dosage adjustments in hepatic impairment are not available. Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Use solution as quickly as possible after drawing through needle into syringe. Anginal pain may be induced when coronary insufficiency is present. ChildrenDose is based on body weight and must be determined by your doctor. Patients should be monitored to confirm that the desired antihypertensive effect is achieved. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Keywords: Blood loss, dacryocystorhinostomy, hemorrhage, induced hypotension . May gradually increase dose if further control is needed. Pharmacist may prepare oral solution from hydralazine injection for patients with difficulty swallowing. Indications And Usage Twenty-five women had more than one episode of hypertension amounting to a total of 109 treatment episodes. It is used to treat hypertension ( high blood pressure ). Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ: (Moderate) Aliskiren can enhance the effects of vasodilators on blood pressure if given concomitantly. Quinidine: (Moderate) Quinidine can decrease blood pressure and should be used cautiously in patients receiving antihypertensive agents due to the potential for additive hypotension. Interactions Drug: beta blockers and other antihypertensive agents compound hypotensive effects. Send the page "" This interaction is used to clinical benefit, i.e., nitroprusside used for supportive care of ergot alkaloid toxicity. Carbetapentane; Phenylephrine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. Sympathomimetics can increase blood pressure and heart rate, and antagonize the antihypertensive effects of vasodilators when administered concomitantly. Furthermore, combination therapy of isosorbide dinitrate and hydralazine, in conjunction with standard therapy, has been shown to improve mortality, rate of first hospitalizations, and quality of life in black patients; a fixed-dose combination of isosorbide dinitrate and hydralazine (BiDIl) is FDA-approved for the treatment of heart failure in black patients. Dobutamine: (Moderate) Use sympathomimetic agents with caution in patients receiving therapy for hypertension. 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